Seminars are typically held on Wednesdays at 1:00PM in-person in CULM 505 or online via Zoom unless otherwise noted. Please note the location listed in the schedule below.
For questions about the seminar schedule, please contact Kristina Wicke.
September 27
Matthew Junge, Baruch College, CUNY
Location: CULM 505
Chase-escape
Stochastic models in which parasite expansion is restricted to the sites occupied by their hosts were introduced by ecologists in the 90s. Most big theoretical questions remain unanswered. I'll describe our efforts to understand these dynamics on lattices, trees, and the configuration model.
October 4
Daniele Avitabile, Vrije Universiteit Amsterdam
Location: TBA
Title: TBA
Abstract: TBA
October 11
Celeste Vallejo, DILIsym/Simulations Plus
Location: Zoom
An Introduction to Mathematical Modeling in Drug Development Using GastroPlus and DILIsym
Modeling and simulation provide support for drug development at all stages of the drug lifecycle. Machine learning models can help to select the lead drug candidate during the drug discovery phase. Physiologically based pharmacokinetic (PBPK) models can help to predict the first-in-human dose during the pre-clinical phase or the appropriate drug dose in special populations during the clinical trial phase. Quantitative systems pharmacology/toxicology (QSP/QST) models can help to predict drug efficacy/toxicity during either the pre-clinical or clinical trial phase. In this talk, I will give a brief introduction to drug development as well as the types of models that are used to solve the most pressing questions in the drug development space. An introduction to PBPK models will be given and the PBPK software, GastroPlus, will be used as illustration. An introduction to QSP/QST models will be given and the QST software, DILIsym, will be used as illustration.
November 1
Deren Eaton, Columbia University
Location: CULM 505
Linking Phylogenetic Inference at Genome-wide and Local Genealogical Scales