Academic Interests: rhythmic motor activity
Farzan Nadim, PhD, is a professor in the department of mathematical sciences at New Jersey Institute of Technology. The main focus of Nadim´s research is to understand how synaptic dynamics, such as short-term depression and facilitation contribute to the generation and control of oscillatory neuronal activity. Such synaptic dynamics are found ubiquitously in all parts of the nervous systems.
Nadim´s research has helped identify new mechanisms through which a fast and a slow oscillatory network coordinate their activities. Elucidating mechanisms through which non-identical networks interact will help us understand, at a cellular and network level, how widespread synchronous patterns arise in large non-homogeneous networks, such as the brain. Such widespread synchronization of rhythmic activity among networks of neurons that normally function to produce distinct behavior can lead to disorders such as generalized epilepsy and Parkinson´s disease.
Grants and Awards
- National Institutes of Health MH-60605 (Principal Investigator) December 2000 (-2011)
- Regulation of Neuronal Oscillations by Synaptic Dynamics
- National Science Foundation DUE-0436244 (Co-Principal Investigator) September 2004 (-2009)
- UBM: An undergraduate biology and mathematics training program at NJIT.
- Binational Science Foundation (co-PI) September 2002 (-2007)
- Mechanisms of Dose- and State-Dependence of Neuromodulation
- Ellen and Albert Grass Faculty Grant (Principal Investigator) Marine Biological Laboratory, 2006
- National Science Foundation IBN-0090250 (Investigator) May 2001 (-2006)
- Research Coordinated Networks: The Pyloric Model Group: Functional Analysis of a
- Complex, Distributed Biological Neural Network
- National Science Foundation DMS-0109876 (co-Investigator) September 2001 (-August 2002)
- Scientific Computing Research Environments for the Mathematical Sciences
- National Science Foundation IBN-0078966 (Principal Investigator) Sept. 2000 (-2001).
- Significance of Synaptic Dynamics in Oscillatory Neuronal Circuits
- Alfred P. Sloan Research Fellowship in Neuroscience, 1999
- NJIT Institutional Funding SBR421140 (Principal Investigator) 1999-2001.
- Associate Professor
Member Center for Applied Mathematics and Statistics, New Jersey Institute of Technology, Newark, NJ.
Faculty Member Integrative Neurocience Program, Rutgers University and University of Medicine and Dentistry of New Jersey, Newark, NJ.
Farzan Nadim studies rhythmic motor activity generated in the central nervous system by combining experiments and computational techniques. Nadim has a joint appointment with the Federated Department of Biological Sciences and runs a laboratory that conducts experiments on isolated nervous systems of crustacea. These experiments involve elecrophysiological recordings from multiple nerves and neurons, pharmacological manipulations of the system, and immunohistology. The neuronal circuits studied all produce oscillatory output of various frequencies. The lab also models these systems both at the detailed biophysical level and using analytic mathematical techniques.
His current focus is on contribution of synaptic dynamics to network output and the interaction between multiple oscillatory systems.
Zhang Y, Bose A and Nadim F: Predicting the activity phase of a follower neuron with A-current in an inhibitory network, Biological Cybernetics, 2008, In Press.
Clewley R, Soto-Trevino C and Nadim F: Dominant ionic mechanisms explored in spiking and bursting using local low-dimensional reductions of a biophysically realistic model neuron, J Computat Neurosci, 2008, In Press. Click for Abstract (Full text at http://dx.doi.org/10.1007/s10827-008-0099-1).
Mouser C, Nadim F and Bose A: Maintaining phase of the crustacean tri-phasic pyloric rhythm, J Math Biology, 57: 161-181, 2008. Click for Abstract
Blitz, D, White RS, Saideman SR, Cook A, Christie A, Nadim F and Nusbaum MP: A newly identified extrinsic input triggers a distinct gastric mill rhythm via activation of modulatory projection neurons, J Exp Biol, 211: 1000-1011, 2008. Click for Abstract
Kintos N, Nusbaum MP and Nadim F: Comparing projection neuron and neuromodulator-elicited oscillations in a motor network, J Comput Neurosci, 24: 374-397, 2008. Click for Abstract (Full text at http://dx.doi.org/10.1007/s10827-007-0061-7).
Rotstein H and Nadim F (2007) Neurons and Neural Networks: Computational Models. In Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester http://www.els.net, doi: 10.1002/9780470015902.a0000089.pub2.
Gansert J, Golowasch J and Nadim F: Sustained rhythmic activity in gap-junctionally coupled neurons depends on the diameter of coupled dendrites, 98:3450-3460, 2007. Click for Abstract (Full text at http://dx.doi.org/10.1152/jn.00648.2007).
Matveev V, Bose A and Nadim F: Describing the bursting dynamics of a two-cell inhibitory network using a one-dimensional map, J Computational Neuroscience, 23: 169-187, 2007. (Full text at http://dx.doi.org/10.1007/s10827-007-0026-x)
Nadim F and Bose A: Dynamics of Central Pattern Generating Networks: Locus of Control, SIAM News: Vol 40 No 2, p 151, 2007. (in pdf form)
Rabbah P and Nadim F: Distinct synaptic dynamics of heterogeneous pacemaker neurons in an oscillatory network, J Neurophysiology, 97: 2239-2253, 2007. (Full text at http://dx.doi.org/10.1152/jn.01161.2006)
Zhou L, Zhao S and Nadim F: Neuromodulation of short-term synaptic dynamics examined in a mechanistic model based on kinetics of calcium currents, Neurocomputing, 70: 2050-2054, 2007. (Full text at http://dx.doi.org/10.1016/j.neucom.2006.10.084)
Drover J, Tohidi V, Bose A and Nadim F: Combining synaptic and cellular resonance in a feed-forward neuronal network, Neurocomputing, 70: 2041-2045, 2007. (Full text at http://dx.doi.org/10.1016/j.neucom.2006.10.135)
Nadim F and Golowasch J: Signal transmission between gap-junctionally coupled passive cables occurs at an optimal cable diameter, J Neurophysiology, 95: 3831-3843, 2006. (Full text at http://dx.doi.org/10.1152/jn.00033.2006)
Smolinski TG, Rabbah P, Soto-Trevino C, Nadim F and Prinz AA: Analysis of biological neurons via modeling and rule mining, International J of Info Tech and Intelligent Computing, 1(2): 293-302, 2006.(In pdf Form).
Zhou L, LoMauro R and Nadim F, The interaction between facilitation and depression of two release mechanisms in a single synapse. Neurocomputing, 69: 1001-1005, 2006. (In pdf Form).
Ambrosio C, Nadim F and Bose A, The effects of varying the timing of inputs on a conditional oscillator. SIAM Journal on Applied Dynamical Systems, 5:108-139, 2006. (In pdf Form).
Rabbah P and Nadim F: Synaptic dynamics do not determine proper phase of activity in a central pattern generator, J. Neuroscience, 25: 11269-11278, 2005. (In pdf Form).
Johnson BR, Schneider LR, Nadim F, Harris-Warrick RM: Dopamine modulation of phasing of activity in a rhythmic motor network: contribution of synaptic and intrinsic modulatory actions. J. Neurophysiology, 94: 3101-3111, 2005. (In pdf Form).
Mamiya A and Nadim F: Target-specific regulation of short-term synaptic depression is important for the function of the synapses in an oscillatory neural network, J. Neurophysiology, 94: 2590 - 2602, 2005. (In pdf Form).
Beenhakker MP, DeLong ND, Saideman SR, Nadim F and Nusbaum MP, Proprioceptor Regulation of Motor Circuit Activity by Presynaptic Inhibition of a Modulatory Projection Neuron. J. Neuroscience, 25: 8794-8806, 2005. (In pdf Form).
Soto-Trevi�o C, Rabbah P, Marder E and Nadim F: A computational model of electrically coupled, intrinsically distinct pacemaker neurons, J. Neurophysiology, 94: 590-604 , 2005. (In pdf Form).
Rabbah P, Golowasch J and Nadim F: Effect of electrical coupling on ionic current and synaptic potential measurements, J. Neurophysiology, 94: 519-530, 2005. (In pdf Form)
Ambrosio C, Bose A, Nadim F: The effect of modulatory neuronal input on gastric mill frequency. Neurocomputing, 65-66: 626-631, 2005. (In pdf Form)
Wood DE, Manor Y, Nadim F and Nusbaum MP: Inter-Circuit Control via Rhythmic Regulation of Projection Neuron Activity, J Neurosci., 24: 7455-7463, 2004. (In pdf Form)
Bose A, Manor Y and Nadim F: The activity phase of postsynaptic neurons in a simplified rhythmic network, J. Comput. Neurosci., 17, 245-261, 2004. (In pdf Form)
Mamiya A and Nadim F: Dynamic interaction of oscillatory neurons coupled with reciprocally inhibitory depressing synapses acts to stabilize the rhythm period, J. Neuroscience, 24: 5140-5150, 2004. (In pdf Form).
Mamiya A, Manor Y and Nadim F: Short-term dynamics of a mixed chemical and electrical synapse in a rhythmic network, J. Neuroscience, 23: 9957-9564, 2003. (In pdf Form)
Manor Y, Bose A, Booth V and Nadim F: Synaptic depression promotes phase invariance in a model rhythmic network, J. Neurophysiology, 90: 3513-3528, 2003. (In pdf Form)
Nadim F, Booth V, Bose A and Manor Y: Short-term synaptic dynamics promote phase maintenance in multi-phasic rhythms, Neurocomputing, 52-54: 79-87, 2003.(In pdf Form)
Manor Y and Nadim F (2001) Synaptic depression mediates bistability in neuronal networks with recurrent inhibitory connectivity, J. Neuroscience, 21: 9460-9470. (In pdf Form)
Nadim, F and Y. Manor (2002) Neurons and Neural Networks: Computational Models, In Encyclopedia of Life Sciences, Macmillan Reference, London. (In pdf Form)
Bose A, Manor Y and Nadim F (2001) Bistable oscillations arising from synaptic depression, 2001, SIAM J. App. Math., 62: 706-727. (In pdf Form)
Nadim F, Manor Y, and Bose A (2001) Control of Network Output by Synaptic Depression, 2001, Neurocomputing, 38-40:781-787. (In pdf Form)
Manor Y and Nadim F (2001) Frequency regulation demonstrated by coupling a model and a biological neuron, 2001, Neurocomputing, 38-40:269-278. (In pdf Form)
Nadim F and Manor Y (2000) The Role of Short-term Synaptic Dynamics in Motor Control. Current Opinion in Neurobiology, 10:683-690. (In pdf Form)
Golowasch J., Y. Manor, F. Nadim.: Recognition of slow processes in rhythmic networks. TINS, 22, 375-377, 1999. (In pdf Form)
Nadim, F., Y. Manor, N. Kopell and E. Marder. Synaptic Depression Creates a Switch That Controls the Frequency of an Oscillatory Circuit. Proc. Natl. Acad. Sci. Vol. 96, 8206-8211, 1999. (In pdf Form)
Bartos M., Y. Manor, F. Nadim, E. Marder, and M. P. Nusbaum: Coordination of Fast and Slow Rhythmic Neuronal Circuits. J. Neurosci. 19: 6650-6660, 1999. (In pdf Form)
Manor, Y., Nadim, F., Epstein, S., Ritt, J., Marder, E., and Kopell, N.: Network Oscillations Generated by Balancing Graded Asymmetric Reciprocal Inhibition in Passive Neurons. J. Neurosci. 19:2765-2779, 1999. (In pdf Form)
Nadim, F., Manor, Y., Nusbaum, M.P., and Marder, E.: Frequency Regulation of a Slow Rhythm by a Fast Periodic Input. J. Neurosci., 18(13): 5053-5067, 1998. (In pdf Form)
- Marder, E., Manor, Y., Nadim, F., Bartos, M., and Nusbaum, M.P.: Frequency Control of a Slow Oscillatory Network by a Fast Rhythmic Input: Pyloric to Gastric Mill Interactions in the Crab Stomatogastric Nervous System. In: Neuronal Mechanisms for Generating Locomotor Activity. (Kiehn O., Harris-Warrick, R.M., Jordan, L.M., Hultborn, H., and Kudo, N. eds.). Annals New York Acad. Sci. 860: 226-238, 1998.
- Nadim, F., Manor, Y., Epstein, S., and Marder, E.: Entrainment of a Slow Neuronal Oscillator by a Fast One. In Computational Neuroscience: Trends in Research, 1998, James M. Bower ed. (Plenum Press, NY).
- Manor, Y., Nadim, F., and Marder, E.: Using the Dynamic Clamp Technique to Study Frequency Regulation of the Pyloric Rhythm. In Computational Neuroscience: Trends in Research, 1998, James M. Bower ed. (Plenum Press, NY).
- Birmingham, J.T., Manor, Y., Nadim, F., Abbott, L.F., and Marder, E.: An Empirical Model Describing the Dynamics of Graded Synaptic Transmission in the Lobster Pyloric Network. In Computational Neuroscience: Trends in Research, 1998, James M. Bower ed. (Plenum Press, NY).
- Manor, Y. and Nadim, F.: Dynamic Synapse Simulator for Studying Neuronal Circuitry Using LabWindows/CVI. In Virtual Instrumentation in Education 1997 Conference Proceedings, National Instruments Corp., 207-216, 1997.
- Nadim, F., Manor, Y., Abbott, L.F., and Marder, E.: Strength and timing of graded synaptic transmission depend on frequency and shape of the presynaptic waveform. In Computational Neuroscience: Trends in Research, 1997, James M. Bower ed. (Plenum Press, NY, 1997).
- Manor, Y., Nadim, F., Nusbaum, M.P., and Marder, E.: Modeling the MCN1-activated gastric mill rhythm: the interaction between fast and slow oscillators. In Computational Neuroscience: Trends in Research, 1997, James M. Bower ed. (Plenum Press, NY, 1997).
Manor, Y., Nadim, F. Abbott, L.F., and Marder, E.: Temporal Dynamics of Graded Synaptic Transmission in the Lobster Stomatogastric Ganglion. J. Neurosci. 17(14):5610-5621, 1997. (In pdf Form)
Nadim, F. and Calabrese, R.L.: A Slow Outward Current Activated by FMRFamide in Heart Interneurons of the Medicinal Leech. J. Neurosci. 17(11)4461-4472, 1997. (In pdf Form)
Olsen, O.H., Nadim, F., Hill, A.V., and Edwards, D.H.: Uniform Growth and Neuronal Integration. J. Neurophysiol., 76:1850-1857, 1996. (In pdf Form)
Nadim, F., Olsen, O.H., De Schutter, E., and Calabrese, R.L.: Modeling the Leech Heartbeat Elemental Oscillator I. Interactions of Intrinsic and Synaptic Currents. J. Comput. Neurosci. 2:215-235, 1995. (In pdf Form)
Olsen, O.H., Nadim, F., and Calabrese, R.L.: Modeling the Leech Heartbeat Elemental Oscillator II. Exploring the Parameter Space. J. Comput. Neurosci. 2:237-257, 1995. (In pdf Form)
Calabrese, R.L., Nadim, F., and Olsen, O.H.: Heartbeat Control in the Medicinal Leech: A Model System for Understanding the Origin, Coordination, and Modulation of Rhythmic Motor Patterns. J. Neurobiol. 27, 394-402, 1995.
Nadim, F., Olsen, O.H., De Schutter, E., and Calabrese, R.L.: The Interplay of Intrinsic and Synaptic Currents in a Half-Center Oscillator. In Neurobiology of Computation, Proceedings of the Third Annual Computation and Neural Systems Conference, James M. Bower ed. (Kluwer, Boston, 1994).